Dr. Jason Keleher, Dr. William Chura and Dr. James Rago
Wound healing poses a formidable challenge especially in cases such as severe burn injuries and battlefield trauma. While there have been significant advances in the past decade with respect to novel wound management materials there are several challenges associated with current technologies. This project seeks to develop "smart" wound management materials that contain biomimetic polymers as the core building block that can be coupled with antimicrobial nanoparticles. The synthetic materials will contain molecular components that can sense and interpret changes to the wound environment and respond appropriately. The proposed project will expand on previously funded research related to novel antimicrobial nanoparticle synthesis to design a functionally responsive wound management material. More specifically the proposed technology will prepare a bioreadsorable polymeric hydrogel nanocomposite that contains Ag-functionalized TiO2 nanoparticles to regulate the growth of bacterial bio-films as well as provide a suitable environment for wound recovery and tissue growth.