Physics, instrumentation and radiochemistry of PET (Positron Emission Tomography). Quality assurance of the PET and PET-CT (computerized tomography) instrumentation. Physiological, biochemical and pharmacological mechanisms of PET radiopharmaceuticals. Radiation safety and protection. Clinical PET imaging in neurological, cardiovascular, oncological and psychiatric disorders. Image reconstruction and display protocols. Case study presentations and journal review.Prerequisite: 02-401, 02-411 or consent of instructor.